Infliximab reverses inflammatory muscle wasting (sarcopenia) in Crohn's disease
نویسندگان
چکیده
منابع مشابه
Mechanisms of muscle wasting in sarcopenia.
Approximately 66% of the patients with rheumatoid arthritis (RA) have significant loss of cell mass (rheumatoid cachexia), mainly of skeletal muscle (rheumatoid sarcopenia). Sarcopenia is defined as muscle wasting associated with functional impairment. Patients with RA possess significant reduction in muscle strength, caused by muscle protein wasting, and loss of functionality. Various conditio...
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Skeletal muscle plays a considerable role in health and disease. Muscle mass is essential for health and survival and plays a major role in mobility as well as morbidity and mortality. There is continual synthesis and degradation of proteins as part of normal metabolism and homeostasis. Equally remarkable, is the characteristic of plasticity allowing muscle to change and adapt depending on the ...
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Human muscle undergoes constant changes. After about age 50, muscle mass decreases at an annual rate of 1-2 %. Muscle strength declines by 1.5 % between ages 50 and 60 and by 3 % thereafter. The reasons for these changes include denervation of motor units and a net conversion of fast type II muscle fibers into slow type I fibers with resulting loss in muscle power necessary for activities of da...
متن کاملEffect of infliximab top-down therapy on weight gain in pediatric Crohns disease.
This retrospective-medical-record review was conducted to evaluate effect of infliximab therapy, particularly with a top-down strategy, on the nutritional parameters of children with Crohns disease (CD). 42 patients who were diagnosed with Crohns disease at the Pediatric Gastroenterology center of a tertiary care teaching hospital and achieved remission at two months and one year after beginnin...
متن کاملPerianal condylomata and HPV-negative ileostomal papillomatous lesion in Crohns disease during Infliximab therapy
A 34-year old woman with Crohns disease during Infliximab treatment presented with tender verrucous lesions in the perianal area and a small verrucous lesion involving the ileostoma. Perianal lesions were enlarged and had a condylomatous appearance, and had become painful. At the same time, a small grayish-white papillomatous plaque on the upper circumference of the ileostoma, with a sharp out...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2015
ISSN: 0269-2813
DOI: 10.1111/apt.13058